We use equity option prices and high frequency stock prices to estimate stock’s variance risk premium (V RP), defined as the difference between the expected variances under the risk-neutral measure and under the empirical measure. Cross-sectionally, V RP is significantly related to stocks ’ sensitivities to common risk factors. In particular, stocks whose returns tend to be low when systematic volatility increases have higher variance risk premium. We find that stock’s expected returns increase with their variance risk premium. Stocks ranked in the top V RP quintile on average outperform those in the bottom quintile by 1.84 % (resp. 1.44%) per month when portfolios are value-weighted (resp. equal-weighted). We reject explanations based on s...